Karyopharm Therapeutics Inc.

  • Senior Director, IT Infrastructure and Operations

    Job Locations US-MA-Newton
    Job ID
    # of Openings
    General & Administrative
    Regular Full-Time
  • Overview

    Karyopharm Therapeutics is a clinical-stage pharmaceutical company focused on the discovery and development of novel first in-class drugs directed against nuclear transport targets for the treatment of cancer and other major diseases.


    This highly visible leadership role is accountable for IT Infrastructure and Operations (I&O) at Karyopharm.  The Senior Director will be responsible for the effective and efficient delivery of all third-party and internally managed IT infrastructure as well as core services used to support business process across the enterprise.  This will be achieved through the effective management and orchestration of the people, products, providers and processes that provide those services.

    As the organization matures, the Senior Director, IT I&O will lead the navigation and management of new challenges in both culture and technology and needs to identify and develop the necessary skills and competencies to meet those challenges.  In many respects, I&O must embrace a stronger service culture, while simultaneously determining how to exploit the emerging technologies.


    A primary area of focus will be the development of robust and collaborative relationships with various business divisions and position I&O to support and drive the digital transformation agenda. The primary end goal being the transformation of IT operations to adopt a more agile approach to how it delivers services.


    Additionally, this leader will oversee the I&O team as they develop the skills required to deliver great customer service and meet the business requirements and associated outcomes.

    The Senior Director should have solid technical infrastructure experience, strong project management acumen and excellent vendor management skills, in addition to a superior, service-oriented and problem-solving approach to infrastructure operations.


    • Sets the mission and vision of the I&O organization to foster a business-oriented culture and mindset driven by continual service improvement techniques.
    • Defines, develops and manages a comprehensive and integrated I&O landscape, based on best-practice processes, disciplines and related toolsets.
    • Operates a formal governance mechanism to ensure that services can continue to be delivered in line with the agreed-on business outcomes.
    • Leads the development of the I&O service strategy and technical roadmap and ensures its integration with the overall IT and enterprise strategic plans.
    • Works with the IT senior leadership team on the service portfolio and governance required to prioritize resources, including budget.
    • Builds and maintains relationships with other IT leaders in the company and key business stakeholders to develop a clear understanding of business needs.
    • Champions I&O involvement in the organization's innovation efforts and its role in experimenting with new solutions to take advantage of business opportunities.
    • Provides oversight for the design, development, operation and support of IT systems that fulfill the needs of the business, including the full life cycle of technical architecture, infrastructure engineering, infrastructure operations and IT service support.
    • Develops and controls the annual operating expenditure (opex) and capital expenditure (capex) budgets for the I&O organization.
    • Leverages influencing and negotiation skills across IT and the enterprise to enable cost-effective and innovative shared solutions in the achievement of business goals.
    • Directs the development of an I&O sourcing strategy and provides oversight for strategic vendor and partner relationship management.
    • Forecasts future skill and competency needs to acquire and develop an IT workforce that provides a balance between growing the agility required to achieve digital business objectives and ensuring that the core IT functions are reliable, stable and efficient.
    • Drives the adoption and commitment to continual service improvement.
    • Maintains currency on new technologies and platforms — including PaaS, IaaS, DaaS, and edge computing.
    • Serves on IT planning and policymaking teams; drives the development of enterprise technology standards, governance processes and performance metrics to ensure that I&O delivers value to the enterprise.



    Bachelors or master's degree in computer science, information systems, business administration or related field, or equivalent work experience


    • Fifteen or more years of experience in IT and business/industry
    • Previous experience in the pharmaceutical industry a must
    • Five to seven years of leadership responsibilities in a related IT operational role, such as system management or service desk management
    • Demonstrated experience in strategic planning, organization design and development
    • Preferably proven experience or demonstrated capability in leading IT transformational initiatives in complex and dynamic environments


    • Strong leadership skills, with the ability to develop and communicate an I&O vision that inspires and motivates the IT staff
    • Ability to build a strong partnership with the business and demonstrate the business value of IT
    • Effective influencing and negotiation skills in an environment in which resources may not be in direct control of this role
    • Strong analytical, strategic conceptual thinking, strategic planning and execution skills
    • Strong business acumen, including industry, domain-specific knowledge of the enterprise and its business units
    • Expertise in budget planning and financial management
    • Deep understanding of current and emerging I&O technologies and practices, and how other enterprises are employing them
    • Application of appropriate regulatory or statutory compliance, including GxP, SOX, GDPR, and information security
    • Success in leveraging traditional best practices, such as ITSM, as well as emerging methods, such as DevOps, that are optimized for agility
    • Demonstrated ability to develop and execute a strategic people plan that ensures the right people are in the right roles at the right time, and employees are highly engaged and satisfied
    • Practical experience in developing and implementing a high-performing ITSM environment and knowledge of "what good looks like"
    • Deliver effective service management through the definition and adoption of a governance practice that uses KPIs and metrics to track and measure the quality of service. Integrates them with key accountabilities to ensure consistency of approach and continual service improvement
    • Strong vendor management and partner relation skills to identify and leverage resources internal and external to the enterprise to enhance capabilities that support business objectives
    • Excellent verbal and written communication skills, including the ability to explain technical concepts and technologies to business leaders, and business concepts to the I&O workforce


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