Karyopharm Therapeutics Inc.

  • Senior Director, Legal Affairs & Contracts Management

    Job Locations US-MA-Newton
    Job ID
    # of Openings
    General & Administrative
    Regular Full-Time
  • Overview

    Karyopharm Therapeutics is a clinical-stage pharmaceutical company, based in Newton, MA, USA, focused on the discovery, development and commercialization of novel, first-in-class agents targeting nuclear transport for the treatment of cancer and other major diseases. Karyopharm is the industry leader in oral Selective Inhibitor of Nuclear Export (SINE) technology, developed to address a central mechanism of oncogenesis via the inhibition of exportins specifically XPO1. Selinexor, Karyopharm’s lead candidate, has been administered to patients with hematologic malignancies or solid tumors in clinical trials worldwide. Karyopharm is currently preparing for its first potential U.S. commercial launch in 2019.



    This role is responsible for leading a team of approximately 10 contracts professionals in a wide variety of areas, including clinical trial agreements and clinical site budgets, and supporting the General Counsel with other matters within the legal department.  A successful candidate has strong leadership, organization and managerial skills. This role is focused on leading the teams that are negotiating contracts and clinical trial site budgets, ensuring appropriate prioritization and execution of all contracts and serving as an escalation point for the team members. The Executive/Senior Director will report to the General Counsel and serve as the single liaison between the contracts group and senior management.



    •   Draft, negotiate and manage company’s contracts (including confidentiality agreements, pre-clinical research agreements, investigator-initiated clinical             trial agreements, master service agreements, consulting agreements, work orders)

    •   Oversee contracting process from initiation to execution including cross-functional management of applicable procedures and policies

    •   Responsible for managing clinical contract and site budget department and clinical contract department vendors

    •   Responsible for contract management systems for clinical and vendor contracts

    •   Responsible for drafting contracts and other document templates and applicable fall back language, and serve as point of contact for any escalated                   contract language

    •   Oversee clinical budget development process; reports to senior management escalation and vendor issues

    •   Oversee negotiation of all clinical trial site contracts and budgets

    •   Support General Counsel and Deputy General Counsel with corporate matters

    •   Other duties as assigned


    •   Proven leadership capabilities

    •   BS/BA

    •   JD preferred

    •   Licensed to practice law in Massachusetts preferred

    •   10+ years’ experience with drafting and negotiating contracts

    •   Team player, energetic, able to handle stress

    •   Strong written verbal and communication skills

    •   Comprehensive knowledge of Microsoft Word, Excel, PowerPoint


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