The Hematology-Oncology Specialist maintains strong professional relationships in the patient care continuum and represents the integrity of Karyopharm Therapeutics by providing approved disease and product information and resources to key decision makers and stakeholders within the oncology community practice setting.   Reporting the Regional Business Director, you will positively impact patients’ when you:   - Develop business plans, market analysis, and strategy that link to strong business results and execute accordingly - Position on-label benefits for appropriate patients to key customer stakeholders to achieve or exceed forecasted sales goals - Resolve issues at account level to ensure access to therapy - Coordinate with colleagues in cross-functional areas including Market Access, Clinical Education, and Medical Affairs to facilitate customer and patient access to Karyopharm product(s) and information - Provide customer feedback to internal stakeholders, sharing best practices, unmet needs, and business opportunities - Assist Marketing function in identifying and inviting appropriate healthcare professionals (HCPs) to promotional and educational events or programs - Develop and maintain mastery of clinical and technical knowledge related to product(s) promoted, the oncology marketplace, and disease management - Foster and develop relationships with Key Opinion Leaders (KOLs), decision makers, influencers, and key stakeholders within the oncology community - Deliver clinical and technical value at medical meetings by staffing promotional booths, as requested - Comply with all laws and regulations and adhere to company compliance guidelines, policy and procedures - Acts with a sense of urgency on behalf of patients and customer

The Data Science Developer will be a key member of the Data Management team and the cross-functional project team on development projects, typically involving large, complex data sets.  This team includes Biostatisticians, Data Scientists, Data Managers, Clinical Project Manager and other organizational stakeholders.  Potential responsibilities include database design, data processing and database loading, and customized data retrieval.  Duties will include participating in company data science and artificial intelligence initiatives.  The ideal candidate is a fast learner, a problem solver, a good communicator, and self-motivated forward thinker.   Reporting to our Head of Data Management, you will positively impact patients’ when you: - Understand clinical trial data, genomic data, and real-world evidence (RWE) data. - Design and utilize an integrated data structure that links multiple data sources that allows for data mining, machine learning, and artificial intelligence. - Oversee, build, and maintain data pipelines to automate data processing tasks. - Support the import and export of data to support the use of an integrated data environment. - Develop and support the User Interface (UI). - Administer and maintain user access to data analytics.

The Manager, Data Management, is responsible for independently leading multiple, high volume and extremely complex studies.  They may also mentor or manage more junior staff. They will lead all clinical data management activities within an assigned study or studies, including direct contact and responsibility for functional oversight of assigned studies.   Reporting to an Associate Director of Data Management, you will positively impact patients’ when you:   - Effective in identifying potential Out of Scope activities while staying within budget, with guidance from Data Management Leadership as needed. - Provide leadership and direction to junior staff and peers, by mentoring, training and guiding a study team to meet study deliverables within the ICH/GCP guidance - Identify and troubleshoot operational problems, issues, obstacles, and barriers for studies based on metrics data, audit reports and input from project team members. - Ability to recognize, evaluate and develop plans to mitigate risk as needed from study initiation to study close-out - Perform all aspects of Data Management as related to processing and QC of the data, monitor study status, (e.g. Enrollment, eCRFs, Query Aging, etc.) and provide status reports to the team throughout the study - Work in conjunction with internal and external Clinical Operations, Research, Data Management and other operational departments to ensure accurate, efficient, and complete data collection - Co-create and review DM SOPs and Work Instructions in accordance with current GCP and ICH guidelines - Responsible for working with database build vendor to develop new EDC databases and subsequent revisions. - Review eCRF completion guidelines, data management plan (DMP), data validation specifications (DVS, e.g. edit checks), SAE Reconciliation Plan, Data Cleaning Plan and other DM related documentation in conjunction with CRO(s) - Assist CRO(s) with cleaning data for Interim Analysis, Database lock, and any add hoc requests. - Liaise with external vendors (Central Labs) in support of timelines and data related deliverables; may also liaise with clinical monitoring in the data management function - Develop data transfer agreements and specifications with various vendors - Identify and troubleshoot operational problems, issues, obstacles, and barriers for studies based on metrics data, audit reports and input from project team members. - Review validation of database structure (DVS), data capture screens, code lists, edit checks, listings and other functions in EDC (e.g. User Acceptance Testing) - Create and review of User Acceptance Test (UAT) Plans and Tests Scripts. - Study level coordination and hands on CDM tasks, including clinical data review - Oversight of external DM and data vendors - Review and provide feedback on Protocols, Statistical Analysis Plans and CSRs - Communicate with functional peers regarding project status and issues and ensure project team goals are met - Represent Karyopharm DM on project teams, at Face-to-Face Meetings, Conferences, etc. - Work in conjunction with external vendors, CRO(s), to Review/Create (electronic) Case Report Forms and annotated Case Report Forms per Protocol - Use industry standard conventions, tools, references and process in support of the coding of Medical History, Adverse Events and ConMeds/ConProcs - Ensures all DM procedures are executed with a high attention to detail, accuracy and timelines - Review and approve study timelines - Monitor timelines and ensure that clinical data management timeline are met with quality - Ensure adherence to Data Management standards. - Ability to travel (~travel time 25%, Global Travel) - Other duties as assigned  

Reporting to our Chief Development Officer, you will positively impact patients’ lives by: Leading all aspects of the development of an assigned program to approval and market entry. In doing so, the Program Lead will provide high level oversight, management, and drive across the span of product development from strategy formulation to execution of that strategy; this encompasses the entire process from preclinical research through registration and market entry.    - Accountable for leading the cross-functional product strategy team to develop the strategy for the product in the target therapeutic area(s), gain approval for that strategy with KPTI leadership and drive the efficient execution of the approved strategy, on time and on budget. - Responsible for integrating the input from various disciplines to create, maintain, and execute product development plans that will result in efficient development of pipeline compounds with a differentiated Target Product Profile as well as any clinical studies and other cross-functional deliverables required for regulatory approval and market access of the assigned compound in multiple regions - Understands the role and contributions of each function to the success of the product development and commercialization and ensures timely and appropriate cross-functional contributions to product strategy development and execution. - Coordinates between all internal/external stakeholders (e.g. Clin Ops, Medical, Pre-clinical, MSLs, Regulatory, Research, Drug supply, Market Access, Commercial, HEOR, Medical Affairs, Publications, Corporate Communications, Investor Relations, Launch Excellence, Alliance Partners as well as Investigators, Patient groups) to ensure alignment, operational efficiency and program success.  - Provides clear direction in a collaborative manner on product development requirements to meet expectations of internal and external customers, patients and business stakeholders. - Responsible to proactively monitor the external landscape and emerging data and recommending adjustments to the approved product strategy, or lifecycle management additions to the strategy as appropriate to ensure the maximal value of the product development plan to Karyopharm and to patients from both a development and commercialization perspective - Responsible for partnering with functional leadership for the high performance of the cross-functional team including coaching team members, or partnering with functional leadership as appropriate - Responsible for driving project performance, risk management, administration, financial management and issue resolution for the cross-functional team. - Ensures quality and compliance of the program team in line with company expectations - May contribute to the identification and evaluation of potential business development opportunities, conduct due diligence evaluations, and development and negotiation of clinical development plans for potential alliances and or in-licensing opportunities - Assesses scientific, medical, and development feasibility, evaluating strategic fit with overall portfolio, evaluating complete or ongoing clinical trials, assessing regulatory interactions and future product development strategic plans interacting with upper management of potential partner/acquisition companies during Due Diligence and alliance negotiations

If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That’s why we’ve built an environment centered around support, flexibility, and a shared mission. Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us – whether that’s onsite, from home, or anywhere in between.    Oursummer intern program, which will run from May 27th– Aug 8th, allows students to gain real world work experience in a high energy, collaborative work culture.    This intern will assist in QMS processes and systems administration to ensure consistent daily operations enabling GxP compliance and inspection-readiness. QMS administration processes include: Document Control, Deviations Management, Investigations Management, CAPA Management, Validation, Change Control, Risk Management, Training Management, Vendor Qualification, and GxP Auditing. Under supervision of functional leads, intern will assist with day-to-day process/system administration and actively participate in QMS administration process improvement projects as assigned. Will interact with 5 functional leads and end users throughout the organization.   This internship will support continuous product supply for Karyopharm’s drug products (IMP) utilized in clinical trials.  The individual will work with the teams managing internal and external tasks and customers in order to accomplish project objectives and to understand the needs of the clinical trials. The Clinical Supply Chain Intern will support Clinical Supply Chain initiatives and continuous improvement activities.   Responsibilities - Participate in cross-functional Project Team Meetings - Partner with PM to review and understand the Clinical Supply study process - Shadow the PM who coordinate and monitor label development process and packaging timelines with the vendors - Learn how to process Temperature Excursions associated to study shipments through approval - Organize and file various trial related documents - Generate Quarterly Reports and the KPTI Performance and Risk Indicators. - Oversight/participation of Clinical Trials processes

The Hematology-Oncology Specialist maintains strong professional relationships in the patient care continuum and represents the integrity of Karyopharm Therapeutics by providing approved disease and product information and resources to key decision makers and stakeholders within the oncology community practice setting.   Reporting the Regional Business Director, you will positively impact patients’ when you:   - Develop business plans, market analysis, and strategy that link to strong business results and execute accordingly - Position on-label benefits for appropriate patients to key customer stakeholders to achieve or exceed forecasted sales goals - Resolve issues at account level to ensure access to therapy - Coordinate with colleagues in cross-functional areas including Market Access, Clinical Education, and Medical Affairs to facilitate customer and patient access to Karyopharm product(s) and information - Provide customer feedback to internal stakeholders, sharing best practices, unmet needs, and business opportunities - Assist Marketing function in identifying and inviting appropriate healthcare professionals (HCPs) to promotional and educational events or programs - Develop and maintain mastery of clinical and technical knowledge related to product(s) promoted, the oncology marketplace, and disease management - Foster and develop relationships with Key Opinion Leaders (KOLs), decision makers, influencers, and key stakeholders within the oncology community - Deliver clinical and technical value at medical meetings by staffing promotional booths, as requested - Comply with all laws and regulations and adhere to company compliance guidelines, policy and procedures - Acts with a sense of urgency on behalf of patients and customer

The Hematology-Oncology Specialist maintains strong professional relationships in the patient care continuum and represents the integrity of Karyopharm Therapeutics by providing approved disease and product information and resources to key decision makers and stakeholders within the oncology community practice setting.   Reporting the Regional Business Director, you will positively impact patients’ when you:   - Develop business plans, market analysis, and strategy that link to strong business results and execute accordingly - Position on-label benefits for appropriate patients to key customer stakeholders to achieve or exceed forecasted sales goals - Resolve issues at account level to ensure access to therapy - Coordinate with colleagues in cross-functional areas including Market Access, Clinical Education, and Medical Affairs to facilitate customer and patient access to Karyopharm product(s) and information - Provide customer feedback to internal stakeholders, sharing best practices, unmet needs, and business opportunities - Assist Marketing function in identifying and inviting appropriate healthcare professionals (HCPs) to promotional and educational events or programs - Develop and maintain mastery of clinical and technical knowledge related to product(s) promoted, the oncology marketplace, and disease management - Foster and develop relationships with Key Opinion Leaders (KOLs), decision makers, influencers, and key stakeholders within the oncology community - Deliver clinical and technical value at medical meetings by staffing promotional booths, as requested - Comply with all laws and regulations and adhere to company compliance guidelines, policy and procedures - Acts with a sense of urgency on behalf of patients and customer