Karyopharm Therapeutics Inc.

Senior Vice President, Chief Business Officer

Job Locations US-MA-Newton
Job ID
# of Openings
General & Administrative
Regular Full-Time


The Senior Vice President, Head of Business Development is responsible for setting the partnering and business strategy for the development and commercialization of all company assets, with a particular focus on the company’s ex-US business strategy.  This role will work closely with the commercial team to execute a strategy for global commercialization of XPOVIO, manage existing and future alliances, and focus on strategy and execution for pipeline expansion.

  • Develop, manage and oversee the execution of Karyopharm’s Business Development Strategy
  • Focus on global development and commercial opportunities for Karyopharm’s assets with both strategic alignment at the highest levels of the organization and tactical execution to grow and maximize enterprise value
  • Facilitate the on-going development of our partnership strategy & manage the overall partner program with broad cross-function collaboration
    • Manage the overall partner strategy supporting our product portfolio needs:  Establish input and feedback channels to gather needs and priorities from various functions and the leadership team, while also adding your own view of opportunitie, Provide frequent updates on partnership development to management
    • Develop and manage SWOT analysis on partnerships relative to major competitors
  • Lead new partner deals
    • Proactively source and evaluate partner candidates to meet our identified business needs
    • Convincingly paint the picture of potential partnership value
    • Respond to partner inquiries in a time-efficient way corresponding to our priorities, while upholding Karyopharm’s reputation in the market
    • Negotiate business terms and handle contracting
  • Spot New Innovation opportunities as they arise.
    • While not a primary focus of the role, the person is well-positioned to identify potential new solutions that marry the capabilities or data from other companies with the solutions from Karyopharm to launch new combined capabilities
  • Develop and present executive presentations in full alignment with executive direction and consensus; develop, present, and manage detailed project/enactment plan for opportunities deemed of interest to the company.
  • Provide periodic detailed and executive level updates to multiple audiences on Business Development activities to ensure awareness and alignment across the organization.


  • Bachelor’s degree required, advanced degree preferred in a scientific discipline with MBA or PhD highly desirable.
  • 15+ years of experience in a highly developed industry, scientific/clinical and business development acumen with the ability to formulate strategies and operational plans that address the interests of the Company, with primary focus and emphasis on Oncology.
  • Demonstrated superior management skill set.
  • Demonstrated history of innovative, “out of the box” thinking and natural penchant for identifying “non-obvious” opportunities that expand/diversify business dynamics; strong strategic agility.
  • Proven track record with out-licensing and value creation with regards to existing partnerships.
  • Superior skill set in Alliance management.
  • Proven track record with a deal sheet which measurably demonstrates ability to lead a high performing search & evaluation function and contribute to successfully executing transactions.
  • Highly developed understanding of global dynamics and contemporary knowledge of the industry landscape.
  • Track record of introducing novel/new business opportunities that are synergistic with the company’s existing operations/assets and potentially provide entry into new areas of strategic focus (additive to early-to-mid stage (traditional) in-licensing and product acquisition opportunities).
  • Keen ability to apply clinical and scientific knowledge (in conjunction with R&D leadership team and other stakeholders) to present and facilitate review and consideration of new opportunities.
  • Knowledge of external healthcare business environment along with an understanding of competitive history and ability to forecast future developments.
  • Applies rigor in assessing new opportunities and effectively leads discussions with key executives to facilitate efficient review and decision making.
  • Excellent aptitude for leading and collaborating with cross-functional teams.


Karyopharm Therapeutics is a global commercial-stage pharmaceutical company focused on the discovery and development of novel first-in-class drugs directed against nuclear transport targets for the treatment of cancer and other major diseases.

Karyopharm Therapeutics Inc. (the "Company") is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law. Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities. If you require an accommodation in the application process, please contact a member of the Company’s Human Resources department.



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