Karyopharm Therapeutics Inc.

Senior Vice President, Marketing

Job Locations US-MA-Newton
Job ID
# of Openings
Regular Full-Time


Reporting to the CCO, the Senior Vice President of Marketing will be responsible for leading the Marketing organization in the development of the marketing strategy, and the planning and execution of tactics to optimize the adoption and use of XPOVIO in the US.  The near-term focus is on maximizing the Mar 2021 launch of XPOVIO in earlier line multiple myeloma. The SVP will also be responsible for developing the marketing strategy for additional indications in hematological malignancies and solid tumors.

The SVP will manage groups responsible for product management for multiple in-line indications, new product planning and marketing operations. The person will also be responsible for assuring launch readiness across Marketing and the Commercial organization as a whole.  This leadership role is responsible for: marketing to all external customers, leading agency and vendor relationships, establishing KOL relationships and leading cross functional collaboration internally and externally.  The SVP will work closely with a breadth of Karyopharm functional groups, including but not limited to Sales, Market Access, Regulatory Affairs, Legal, Medical Affairs, as well as business partners to ensure organizational alignment with the commercialization strategy of XPOVIO. 

In this leadership position, this executive will help establish commercial and corporate goals, and to advocate for the required budget and resources from the executive team and board of directors.

  • Hire, coach, develop, and retain staff members. Create compelling and robust development and succession plans for all key positions within the function.
  • Continue the development of the marketing team members including product management, marketing operations and new product planning.
  • Inspire, align, mentor, motivate and mobilize teams.
  • Lead, develop and execute the XPOVIO marketing strategy including identification of key market issues, critical success factors for the brand, design of solutions, brand vision, positioning and messaging including competitive strategies and marketing tactics. 
  • Drive innovation in strategy and tactics to build brand awareness, excitement and intent to prescribe.
  • Build incremental capabilities in Marketing to drive success and position Karyopharm as a leader in Marketing.
  • Work across all Commercial functions to establish performance targets and measurement plans.
  • Oversee and deliver on the execution of compliant US brand marketing plans and programs, including developing and managing the marketing budgets, developing and refining department procedures (SOPs) with Marketing Operations; and managing, mentoring and developing organizational resources.
  • Identify and align on market research needs, and plans with Commercial Analytics, and translate competitive intelligence insights into product strategies and forecasting assumptions. 
  • Work collaboratively with key thought leaders, academic institutions, cooperative groups, and professional and patient advocacy groups to validate commercial approach and secure launch readiness for additional indications in the US.
  • Work with agency of record, strategic consultants, and other vendors as necessary to develop launch programming and ensure superior execution of tactics.
  • Provide input on payer/pricing strategies through product life cycle.
  • Monitor and manage brand marketing budgets and forecasts, while evaluating cost effectiveness and ROI of activities and results.
  • Demonstrate company values on a consistent basis.  Acts, and is accountable for others in his/her team to act, in compliance with all laws, regulations and policies.



  • BA/BS degree in business, marketing or science required. MBA preferred
  • Strong history and proven track record of building and leading high performing Marketing teams; ability to coach and develop people
  • Experience with commercialization of oncology therapies required, including launch experience
  • Minimum of 15+ years of pharmaceutical and/or healthcare experience with a minimum of 8+ years in US pharmaceutical pre-launch and launch marketing
  • Experience managing marketing and market research functions and budgets
  • Demonstrated strategic thinking, innovative solutions to marketing challenges, initiative, creativity in positioning and marketing oncology products.  The ideal candidate would have in-line marketing experience of oncology products, US pharmaceutical sales experience a plus
  • Demonstrated understanding of marketing opportunity analysis, market building tools and strategy
  • Strong business acumen, strategic thinking, analytical/financial skills
  • Excellent communication and collaboration skills, ability to collaborate cross functionally with all stakeholders in a small and entrepreneurial team
  • High ethical standards, including demonstrated adherence to all corporate, Compliance, and Regulatory guidelines and procedures


Karyopharm Therapeutics is a global commercial-stage pharmaceutical company focused on the discovery and development of novel first-in-class drugs directed against nuclear transport targets for the treatment of cancer and other major diseases.

Karyopharm Therapeutics Inc. (the "Company") is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law. Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities. If you require an accommodation in the application process, please contact a member of the Company’s Human Resources department.


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