Karyopharm Therapeutics Inc.

Senior Manager, Site Relationship & Recruitment Lead

Job Locations US-Remote
Job ID
# of Openings
Clinical Operations
Regular Full-Time

Role Overview & Key Functions:

The Site Relationship and Recruitment Lead is a pivotal role within our Clinical Operations team, responsible for establishing and nurturing strong relationships with research sites and overseeing the engagement and recruitment strategies for clinical trials. This role requires a proactive and detail-oriented professional with exceptional interpersonal skills and a deep understanding of clinical research processes


Reporting to the Director of Field Excellence, you will positively impact patients’ when you: 


  • Develop site engagement tools and strategies to drive site recruitment across assigned study(ies)
  • Partner with clinical study team and Global Medical and Scientific Affairs (GMSA), when applicable, to develop study and/or program level site engagement and recruitment plans (SERPs) and additional strategies to deploy to the field team.
  • In collaboration with assigned sites, develop site specific engagement and recruitment plans, and discuss site recruitment strategies and tactics to meet study goals.
  • Partner with clinical trial sites, CRO, alliance partners and GMSA, when appropriate, to maintain SERPs and drive implemented strategies.
  • Maintain regular and proactive communication with sites to address site recruitment strategy delays, issues and concerns.
  • Communicate enrollment expectations to sites, address concerns, barriers and escalate to appropriate stakeholders for resolution.
  • Ensure that recruitment strategies with sites adhere to all relevant regulations, guidelines, and ICH/GCP standards.
  • Leverage lessons learned to course correct and adjust site engagement strategies as needed.
  • Communicate with clinical operations team, medical, and other internal/external stakeholders to share barriers and insights related to site recruitment and retention and propose mitigations to address.
  • Partner with the clinical operations team and medical to optimize site communication strategies that impact site engagement and recruitment.
  • Maintain thorough knowledge of disease state, compound and protocols to optimize site relationship and engagement.
  • Ensure accurate and up-to-date records of site interactions, recruitment activities, and progress towards enrollment goals.
  • Provide regular updates on study site recruitment status, plans to address any noted barriers and potential areas for improvement. In addition, confirm that engagement and recruitment strategies are effective at meeting study goals with an ability to shift as needed.
  • May participate in cross-functional initiatives to support business execution.

Candidate Profile & Requirements:

  • Bachelor's degree preferred, HS diploma required.
  • A minimum of 8 years of relevant clinical research experience. Global experience preferred.
  • Experience driving site engagement and recruitment strategies.
  • Understanding of drug development process, GCP and ICH clinical requirements
  • Experience communicating with site staff including KOLs and experts.
  • Ability to influence without authority.
  • Collaborate with internal and external stakeholders.
  • Conflict resolution skills.
  • Oncology experience preferred.
  • Excellent communication, Excel and PowerPoint skills.
  • Travel up to 50%


Our Value Proposition:

At Karyopharm, we live and demonstrate our ICARE values every day!


Creating and delivering medicine for serious disease can only be done through focus, collective dedication, and heart. We’re the people who aren’t afraid of a headwind, don’t get rattled by the external noise, and continue to stay focused for our patients who are depending on us. We work collaboratively and tirelessly on our strategy to bring ideas into reality. 

Patients and the people who love them fight for every minute of every day. We believe focusing our days on delivery of our four core programs will make a profound difference in their lives.  

Our expertise is vast, our organization is nimble, and our potential transformative. Together, we are working fearlessly to defeat cancer.

Please check out our Culture Video!


What We Offer:


In addition to our exciting, supportive, and intellectually challenging global workspaces(s), Karyopharm employees enjoy a comprehensive and generous benefits package (active on day one) that makes them more productive and contributes directly to the development of their professional skills.


  • A fun, collaborative, work environment
  • A culture of employee engagement, diversity, and inclusion
  • Competitive salary, bonus, and generous equity offerings (RSU’s at time of offer and annual awards) – we are partners in prosperity!
  • Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), and tuition reimbursement.
  • Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends.
  • Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development programs, and a variety of reward and recognition programs)
  • Cell phone allowance
  • In the U.S., the salary range for this position is $130,000 to $170,000 per year, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors

* This position is eligible for remote/hybrid working arrangement (may work from home/virtually; may also work hybrid on-site-virtual as required/approved by hiring manager.






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