Karyopharm Therapeutics Inc.

Clinical Account Director (CAD)

Job Locations US-Remote
Job ID
2026-2428
# of Openings
1
Category
Commercial
Type
Regular Full-Time

Role Overview & Key Functions:

The Clinical Account Director (CAD) will play a critical role in ensuring that Karyopharm and its products are well positioned for extensive customer/patient access at launch and ongoing revenue target achievement and growth within the assigned accounts. The CAD role will be broad in scope of responsibility, account base, and internal customer partnerships. Ultimately, the CAD will enhance Karyopharm business growth by identifying strategic partnering opportunities, developing business plans to capitalize on those opportunities, and optimally executing the plans in each account. When working with the assigned accounts, the CAD will partner with multiple internal resources and functional areas including, but not limited to, marketing, sales/sales leadership, medical/clinical, finance, legal, and the broader Market Access team to achieve corporate objectives. This role reports to the Senior Director, Corporate Accounts. 

 

RESPONSIBILITIES:

  • Develop and lead the Karyopharm partnership with multiple key contacts across all accounts
  • Identify opportunities to leverage Karyopharm products across market segments, both directly and indirectly
  • Plan, initiate, negotiate and manage profitable business relationships and contracts with assigned accounts
  • Develop and execute account specific business plans and provide ongoing business updates to Market Access team and other internal partners
  • Manage and maximize internal resources, both financial and human, in meeting planned objectives with each customer
  • Ensure compliance with all applicable laws, regulations, and guidelines
  • Work collaboratively with Market Access colleagues and multiple functional areas in developing strategic and tactical plans
  • Participate and assist in the planning of overall brand and corporate strategies on an ongoing basis and as part of various sub-teams and committees as needed
  • Be viewed as the subject matter expert on assigned accounts, market segments, and issues that impact our relationship and ability to work with them
  • Manage administrative and fiduciary duties as appropriate to the CAD role
  • Operate within the framework of Karyopharm’s Corporate Values

Candidate Profile & Requirements:

QUALIFICATIONS:

  • Bachelor’s degree required
  • 10 years of relevant experience in Biotech/ pharmaceutical or Oncology space
  • 3 years of Account Management experience in Biotech/pharmaceutical or Oncology space
  • Comprehensive understanding of the key organizations and decision makers in the Oncology space
  • Experience working with multiple Oncology market segments (ie GPO, SD, SP, Oncology focused institutions, other relevant partner organizations)
  • Thorough knowledge of contracting process and terminology, language and expectations required.
  • Proven ability to develop account level strategic and tactical plans, successfully executing against measurable metrics.
  • High level of financial acumen and negotiations skills.
  • Experience and success in generating and negotiating agreements within the Oncology space
  • Willingness to work independently in a fast-paced environment, with the ability to multi-task and self-prioritize workload.
  • Willingness to travel up to 60 percent of time, which will include regional and national travel.
  • Exceptional communication, interpersonal and relationship building skills
  • Demonstrated leadership ability with a focus on influence, impact and leading without formal lines of authority.
  • Demonstrated skills working cross functionally with internal customers
  • Demonstrated skills in building and executing business plans
  • Experience in Oncology sales leadership preferred
  • Launching of new product/start-up experience highly preferred
  • Experience with oral Oncology products highly preferred

 

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $225K-270K USD.

Our Value Proposition:

This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs. 

 

Our lead therapy, XPOVIO® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.  

 

As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued. 

 

Learn more at Karyopharm Therapeutics

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