We are seeking a highly motivated and detail-oriented Staff or Senior Accountant to join our dynamic Finance team. This role is a key contributor to the monthly and quarterly close process, with a focus on general and administrative (G&A) accruals, balance sheet account reconciliations, and support for accounts payable operations. The successful candidate will work closely with the Assistant Controller and cross-functional teams to ensure timely and accurate financial reporting, support public filing requirements, and maintain a strong internal control environment.

Key Responsibilities

• Prepare monthly and quarterly journal entries related to G&A accruals and other expense categories.
• Perform balance sheet account reconciliations and ensure accuracy and compliance with US GAAP.
• Assist with the day-to-day operations of the accounts payable function, including reviewing invoices, ensuring accurate coding, and supporting vendor inquiries.
• Contribute to the month-end and quarter-end close process, including preparation of financial reporting support schedules.
• Participate in the tie-out of quarterly and annual public filings (10-Q, 10-K), including preparation of supporting documentation and audit deliverables.
• Support the companies’ activities with external auditors and internal auditors

• Bachelor’s degree in Accounting, Finance, or related field required.
• CPA or CPA track preferred.
• 2–5 years of relevant accounting experience, preferably in a public company or public accounting firm.
• Strong understanding of US GAAP and internal controls.
• Experience with Great Plains preferred and proficiency in Excel.
• Excellent organizational, analytical, and problem-solving skills.
• Strong interpersonal and communication skills with the ability to work effectively in a collaborative environment.
• Self-starter with the ability to manage multiple priorities and meet deadlines.

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $105–$120k USD.

At Karyopharm, we live and demonstrate our ICARE values every day!

If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That’s why we’ve built an environment centered around support, flexibility, and a shared mission.

Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us – whether that’s onsite, from home, or anywhere in between.

What do you get when you pair an extraordinary mission with a culture of flexibility and empowerment? We invite you to find out and join us on this incredible mission.

Check out our Culture Video!

What We Offer:

In addition to our exciting, supportive, and intellectually challenging global workspaces(s), team members enjoy a comprehensive and generous benefits package (active on day one) that makes them more productive and contributes directly to the development of their professional skills.

• A culture of employee engagement, diversity, and inclusion
• Competitive salary, bonus, and generous equity offerings (RSU’s at time of offer and annual awards) – we are partners in prosperity!
• Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), ESPP and tuition reimbursement.
• Wellness Program with a monthly stipend. 
• Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends.
• Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development & mentoring programs, and a variety of reward and recognition programs)
• Cell phone allowance