Karyopharm Therapeutics Inc.

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Welcome to our careers page! Here you can view our current job openings and apply for positions online.

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Karyopharm Therapeutics Inc. (the "Company") is an equal opportunity employer.  All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law.  Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities.  If you require an accommodation in the application process, please contact a member of the Company’s Human Resources department. 

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Job Locations US-Remote
We are seeking an enthusiastic Senior Manager/Associate Director of Medical Communications to lead critical initiatives in shaping medical and scientific narratives. This role requires expertise in therapeutic landscapes, leadership skills to advance cross functional projects, and leading the development of communication plans that align with strategic imperatives. This individual will drive the creation of innovative resources for external engagement, oversee the development of scientific communication platforms, and manage content for medical affairs booths, symposia, and digital assets. If you thrive in a fast-paced environment and excel in delivering...
Job ID
2025-2326
Job Locations US-Remote
  The Medical Director will serve as the primary medical lead for Karyopharm study team within assigned clinical trials and with cross-functional teams on clinical trial strategy, design and execution. Along with this, the Medical Director will serve as the primary Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. This individual may work on multiple trials to include solid tumor(s), myeloma and other hematological studies.
Job ID
2025-2325
Job Locations US-Remote
Join our team as a Regulatory Affairs Manager and play a pivotal role in shaping the success of our global regulatory strategies. In this position, you will lead critical regulatory submissions, drive agency interactions, and ensure compliance with evolving regulatory standards. From managing labeling initiatives and regulatory intelligence projects to co-chairing cross-functional subteams, you will be at the forefront of...
Job ID
2024-2324
Job Locations US-Remote
The  Principal Statistical Programmer will play a critical role in advancing clinical trial research and regulatory submissions. This position offers the opportunity to lead statistical programming efforts, including developing and validating datasets, creating files for regulatory submissions, and collaborating with cross-functional teams to ensure compliance with CDISC data standards. If you’re passionate about driving excellence in statistical programming and contributing to life-changing clinical development programs, this role provides the perfect platform to make a meaningful impact.   Reporting to our Senior...
Job ID
2024-2320
Job Locations US-Remote | US-IL | US-MO
The Senior MSL is an experienced oncology professional with scientific, clinical, and therapeutic area expertise responsible for providing medical expertise on all the Karyopharm assets in development. This individual is a highly valuable member of the Global Medical and Scientific (GMSA) team who represents Karyopharm externally by engaging in highly credible scientific discussions with targeted Key Opinion Leaders (KOLs), internal stakeholders, clinical trial investigators, access stakeholders and other healthcare professionals to help support the medical objectives at Karyopharm.  We are looking for someone who approaches the role with thoughtful consideration of the future.
Job ID
2024-2317
Job Locations US-Remote | US-NY | US-NJ
The Senior MSL is an experienced oncology professional with scientific, clinical, and therapeutic area expertise responsible for providing medical expertise on all the Karyopharm assets in development. This individual is a highly valuable member of the Global Medical and Scientific (GMSA) team who represents Karyopharm externally by engaging in highly credible scientific discussions with targeted Key Opinion Leaders (KOLs), internal stakeholders, clinical trial investigators, access stakeholders and other healthcare professionals to help support the medical objectives at Karyopharm.  We are looking for someone who approaches the role with thoughtful consideration of the future.
Job ID
2024-2315
Job Locations US-Remote
We are seeking an experienced and detail-oriented regulatory affairs professional to join our team as a Director of Regulatory Submissions. This critical role will oversee the planning, management, and execution of regulatory submissions, ensuring high-quality dossiers that meet global regulatory standards. Acting as a strategic partner and conduit between cross-functional teams, this individual will streamline submission processes and drive continuous improvement in tools, templates, and SOPs. With a focus on collaboration and excellence, this role is pivotal in ensuring timely, accurate submissions that align with organizational objectives and regulatory requirements
Job ID
2024-2314
Job Locations US-Remote
The Sr Director, Clinical Research Scientist position serves a key role within the Clinical Development R&D team.  The Sr Director, CRS works closely with the assigned study team(s) and medical director(s) to support the activities associated with one or more clinical studies. This position collaborates with clinical team members as well as with functions outside of clinical to provide high quality and timely deliverables.    Reporting to our Senior Vice President, Clinical Development, you will positively impact patients’ when you: - Support assigned...
Job ID
2024-2311